General Information

  • ID:  hor000235
  • Uniprot ID:  Q23756
  • Protein name:  Pigment-dispersing hormone
  • Gene name:  PDH2
  • Organism:  Callinectes sapidus (Blue crab)
  • Family:  Arthropod PDH family
  • Source:  Animal
  • Expression:  Eyestalk sinus gland.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Callinectes (genus), Portuninae (subfamily), Portunidae (family), Portunoidea (superfamily), Heterotremata, Eubrachyura, Brachyura (infraorder), Pleocyemata (suborder), Decapoda (order), Eucarida (superorder), Eumalacostraca (subclass), Malacostraca (class), Multicrustacea (superclass), Crustacea (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction; GO:0007268 chemical synaptic transmission
  • GO CC:  GO:0005576 extracellular region; GO:0045202 synapse

Sequence Information

  • Sequence:  QELHVPEREA
  • Length:  10(22-31)
  • Propeptide:  MRSGVFVAVLVVVVFALLTQGQELHVPEREAVANLAARILKIVHAPHDAAAGVPHKRNSELINSLLGISALMNEAGRR
  • Signal peptide:  MRSGVFVAVLVVVVFALLTQG
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Induces light-adaptive movement of pigment in distal eye pigment cells and?pigment dispersion
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q23756-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor000235_AF2.pdbhor000235_ESM.pdb

Physical Information

Mass: 136802 Formula: C51H82N16O18
Absent amino acids: CDFGIKMNSTWY Common amino acids: E
pI: 4.47 Basic residues: 2
Polar residues: 0 Hydrophobic residues: 3
Hydrophobicity: -135 Boman Index: -3478
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 78
Instability Index: 6490 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  21740068
  • Title:  Discovery and Characterization of the Crustacean Hyperglycemic Hormone Precursor Related Peptides (CPRP) and Orcokinin Neuropeptides in the Sinus Glands of the Blue Crab Callinectes Sapidus Using Multiple Tandem Mass Spectrometry Techniques